Review. NIRS in neonatal intensive care

Several instruments implementing spatially resolved near-infrared spectroscopy (NIRS) to monitor tissue oxygenation are now approved for clinical use. The neonatal brain is readily assessible by NIRS and neurodevelopmental impairment is common in [...]

Review. NIRS and muscle oxygenation physiology

This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 summarizing the recent literature, offering the present status and perspectives of the NIRS instrumentation and methods, describing the main NIRS studies [...]



Review. Shedding light on adult brain

Near-infrared spectroscopy (NIRS) has potential as a non-invasive brain monitor in a wide range of clinical scenarios. In the last decade, there has been a rapid expansion of clinical experience using NIRS to monitor cerebral oxygenation, [...]

Clinical optical and optoacoustic imaging

Macroscopic optical imaging has rather humble technical origins; it has been mostly implemented by photographic means using appropriate filters, a light source and a camera yielding images of tissues. This approach relates to human vision and [...]

Review. Optical imaging in drug discovery

Optical technologies used in biomedical research have undergone tremendous development in the last decade and enabled important insight into biochemical, cellular and physiological phenomena at the microscopic and macroscopic level. Historically in [...]



Review. Hb oxygenation as a biomarker

Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen [...]

Review. Towards the next generation

Although near-infrared spectroscopy (NIRS) was originally designed for clinical monitoring of tissue oxygenation, it has also been developing into a useful tool for neuroimaging studies (functional NIRS). Over the past 30 years, technology has [...]

A human ventricular cell model

In this study, several modifications were introduced to a recently proposed human ventricular action potential (AP) model so as to render it suitable for the study of ventricular arrhythmias. These modifications were driven by new sets of [...]

Modelling of liver tumour ablation

The treatment of cancerous tumours in the liver remains clinically challenging, despite the wide range of treatment possibilities, including radio-frequency ablation (RFA), high-intensity focused ultrasound and resection, which are currently [...]

Review. Quantities in biological medicines

A distinction exists between ‘chemical’ and ‘biological’ medicines. While, from antiquity, both organic and inorganic substances had been used in therapy, developing chemical sciences were inapplicable to materials extracted [...]