Single Nucleotide Polymorphism in Gene Encoding Transcription Factor Prep1 Is Associated with HIV-1-Associated Dementia

by Sebastiaan M. Bol, Thijs Booiman, Daniëlle van Manen, Evelien M. Bunnik, Ard I. van Sighem, Margit Sieberer, Brigitte Boeser-Nunnink, Frank de Wolf, Hanneke Schuitemaker, Peter Portegies, Neeltje A. Kootstra, Angélique B. van ‘t Wout
Background [...]

Prevention of Apoptosis by Mitochondrial Phosphatase PGAM5 in the Mushroom Body Is Crucial for Heat Shock Resistance in Drosophila melanogaster

by Yosuke Ishida, Yusuke Sekine, Haruka Oguchi, Takahiro Chihara, Masayuki Miura, Hidenori Ichijo, Kohsuke Takeda

The heat shock (HS) response is essential for survival of all organisms. Although the machinery of the HS response has been [...]



Three Dimensional Visualization and Fractal Analysis of Mosaic Patches in Rat Chimeras: Cell Assortment in Liver, Adrenal Cortex and Cornea

by Stephen Iannaccone, Yue Zhou, David Walterhouse, Greg Taborn, Gabriel Landini, Philip Iannaccone

The production of organ parenchyma in a rapid and reproducible manner is critical to normal development. In chimeras produced by the [...]

Smoking, Green Tea Consumption, Genetic Polymorphisms in the Insulin-Like Growth Factors and Lung Cancer Risk

by I-Hsin Lin, Ming-Lin Ho, Hsuan-Yu Chen, Hong-Shen Lee, Chia-Chen Huang, Yin-Hung Chu, Shiau-Yun Lin, Ya-Ru Deng, Yu-Hao He, Yu-Hui Lien, Chi-Wen Hsu, Ruey-Hong Wong

Insulin-like growth factors (IGFs) are mediators of growth hormones; they [...]

Genomic Analysis of wig-1 Pathways

by Yalda Sedaghat, Curt Mazur, Mahyar Sabripour, Gene Hung, Brett P. Monia
Background Wig-1 is a transcription factor regulated by p53 that can interact with hnRNP A2/B1, RNA Helicase A, and dsRNAs, which plays an important role in RNA and protein [...]



Antimetastatic Effects of Norcantharidin on Hepatocellular Carcinoma by Transcriptional Inhibition of MMP-9 through Modulation of NF-kB Activity

by Chao-Bin Yeh, Ming-Ju Hsieh, Yi-Hsien Hsieh, Ming-Hsien Chien, Hui-Ling Chiou, Shun-Fa Yang
Background The rate of morbidity and mortality of hepatocellular carcinoma (HCC) in Taiwan has not lessened because of difficulty in treating tumor [...]

Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

by Iris Z. Uras, Thomas List, Sebastian M. B. Nijman
Background Phosphorylation by the phospho-inositide-dependent kinase 1 (PDK1) is essential for many growth factor-activated kinases and thus plays a critical role in various processes such as cell [...]

RNA Interference of NADPH-Cytochrome P450 Reductase Results in Reduced Insecticide Resistance in the Bed Bug, Cimex lectularius

by Fang Zhu, Sarah Sams, Tim Moural, Kenneth F. Haynes, Michael F. Potter, Subba R. Palli
Background NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochrome P450 action. The genes coding for P450s are not yet fully identified in the [...]

Eco-Virological Approach for Assessing the Role of Wild Birds in the Spread of Avian Influenza H5N1 along the Central Asian Flyway

by Scott H. Newman, Nichola J. Hill, Kyle A. Spragens, Daniel Janies, Igor O. Voronkin, Diann J. Prosser, Baoping Yan, Fumin Lei, Nyambayar Batbayar, Tseveenmyadag Natsagdorj, Charles M. Bishop, Patrick J. Butler, Martin Wikelski, Sivananinthaperumal [...]

Maternal Malaria Induces a Procoagulant and Antifibrinolytic State That Is Embryotoxic but Responsive to Anticoagulant Therapy

by John W. Avery, Geoffrey M. Smith, Simon O. Owino, Demba Sarr, Tamas Nagy, Stephen Mwalimu, James Matthias, Lauren F. Kelly, Jayakumar S. Poovassery, Joab D. Middii, Carlos Abramowsky, Julie M. Moore

Low birth weight and fetal loss are [...]