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A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to [...]

[Podcast] Science Podcast

The show includes how social network structure affects the spread of behavior, challenging the mammoth-killer impact hypothesis, your letters to Science, and [...]



[Report] Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

Pathogenic bacterial proteins interfere with eukaryotic ubiquitination pathways to induce cytopathic effects.

Authors: Jixin Cui, Qing Yao, Shan Li, Xiaojun Ding, Qiuhe Lu, Haibin Mao, Liping Liu, Ning Zheng, She Chen, Feng [...]

[Report] The Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3K

Ligand engagement and initiation of signaling has been imaged for a costimulatory receptor for immune cells in the skin.

Authors: Petra Verdino, Deborah A. Witherden, Wendy L. Havran, Ian A. [...]

[Report] Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

The energy sensor AMPK facilitates gene transcription by localizing to chromatin and phosphorylating histone H2B.

Authors: David Bungard, Benjamin J. Fuerth, Ping-Yao Zeng, Brandon Faubert, Nancy L. Maas, Benoit Viollet, David Carling, Craig B. Thompson, Russell G. Jones, Shelley L. [...]



[Report] The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial γδ T Cell Activation

A costimulatory receptor for immune cells in the skin is identified.

Authors: Deborah A. Witherden, Petra Verdino, Stephanie E. Rieder, Olivia Garijo, Robyn E. Mills, Luc Teyton, Wolfgang H. Fischer, Ian A. Wilson, Wendy L. [...]

[Report] Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

Bacterial colonization of the mucosa is facilitated if the microbes engage a human receptor that counteracts epithelial exfoliation.

Authors: Petra Muenzner, Verena Bachmann, Wolfgang Zimmermann, Jochen Hentschel, Christof R. [...]

[Report] The Spread of Behavior in an Online Social Network Experiment

An online experiment shows how network structure affects the spread of health behavior.

Author: Damon [...]

[Report] Graphene Visualizes the First Water Adlayers on Mica at Ambient Conditions

Water trapped between mica and graphene layers at ambient conditions was imaged with atomic force microscopy.

Authors: Ke Xu, Peigen Cao, James R. [...]

[Report] The Shifting Balance of Diversity Among Major Marine Animal Groups

Future assemblies of animals following mass extinction cannot be predicted by analyses of Phanerozoic fossils.

Author: J. [...]